Project Team Leader, Biology

Orum Therapeutics

Project Team Leader advancing Orum Therapeutics’ oncology drug discovery programs from target validation through IND. Leading biology strategy across targeted protein degradation and antibody-drug conjugate modalities.

Posted 8/12/2026full-timeLexington • Massachusetts • 🇺🇸 United StatesSenior💰 $175,000 - $200,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

Use this summary to align your resume positioning with the role.

Expertise in leading oncology discovery programs, including target validation and IND-enabling studies, with a strong focus on targeted protein degradation and antibody-drug conjugates. Proven ability to mentor junior scientists and collaborate cross-functionally to drive research strategy and execution.

Highest-signal resume keywords

PhD In Cancer BiologyTargeted Protein DegradationAntibody-Drug ConjugatesIn Vivo Oncology Pharmacology StudiesCross-Functional Collaboration

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Target ValidationHit-To-LeadLead OptimizationIND-Enabling StudiesE3 Ligase BiologyMolecular GluesDegradation AssaysXenograft/PDX StudiesPK/PD AnalysisEfficacy Studies

Soft Skills

MentoringScientific GuidanceData Communication

Tools & Technologies

CRO ManagementDosing DesignData Integrity

Industry Keywords

OncologyPharmacologyBiochemistryMolecular BiologyCancer Biology

About the role

Key responsibilities & impact

Lead the biology strategy and execution for one or more oncology discovery programs spanning target validation, hit-to-lead, lead optimization, and IND-enabling studies
Design and oversee in vitro and in vivo plans for degrader and degrader antibody conjugate candidates
Serve as the biology representative on cross-functional project teams with chemistry, DMPK, toxicology, CMC, and translational functions
Translate research strategy into workplans, timelines, and go/no-go criteria; anticipate risks and propose data-driven mitigations
Coordinate and oversee in vivo studies, including scoping, CRO selection and management, dosing design, and data integrity
Mentor and provide scientific guidance to junior scientists
Analyze, interpret, and communicate data and program status to research leadership and the broader organization
Contribute to target evaluation, portfolio strategy, and new program concepts

Requirements

What you’ll need

PhD in cancer biology, molecular/cell biology, pharmacology, biochemistry, or a related field, with 8+ years of experience, or a Master's degree with 12+ years of commensurate experience
Demonstrated record of independently leading discovery programs
Demonstrated track record advancing oncology discovery programs toward IND
Program-level or hands-on experience with targeted protein degradation, including E3 ligase biology, molecular glues and/or PROTACs, ternary complex formation, and degradation assays
Experience with antibody-drug conjugates, including target/antigen selection, internalization, linker-payload biology, DAR, bystander effect, and characterization
Ability to design and interpret in vivo oncology pharmacology studies, including xenograft/PDX, PK/PD, and efficacy
Experience managing CRO-run studies
Strong record of cross-functional collaboration across discovery and development
U.S. citizenship or authorization to work in the U.S.; employer unable to sponsor or transfer at this time
Ability to pass a background investigation

Benefits

Comp & perks

🌐 Worldwide ❌ Jobs You've Hidden ⭐️ Saved Jobs ✅ Applied Jobs ✉️ Email Alerts 👤 Account Orum Therapeutics Website LinkedIn All Job Openings 11 - 50 employees Founded 2016 🏥 Healthcare 💼 Consulting 🏭 Manufacturing Healthcare
Consulting
Manufacturing Orum Therapeutics is a clinical-stage biotechnology company that pioneers a novel class of antibody-drug conjugates (ADCs). The company develops innovative therapies that combine the efficacy of protein degraders with the precision of antibodies to change the landscape of disease treatment. Through its advanced TPD² cell-selective degradation technology, Orum aims to improve the efficacy, safety, and pharmacokinetics of targeted therapies. Project Team Leader, Biology Job not on LinkedIn 🔥 0 minutes ago 🏢🏡 Lexington – Hybrid 💵 $175k - $200k / year ⏰ Full Time 🟠 Senior ✨ Team Leader Apply Now Customize resume + cover letter Report problem ☆ Save ☑️ Mark as applied ❌ Hide 📋 Description
Lead the biology strategy and execution for one or more oncology discovery programs spanning target validation, hit-to-lead, lead optimization, and IND-enabling studies
Design and oversee in vitro and in vivo plans for degrader and degrader antibody conjugate candidates
Serve as the biology representative on cross-functional project teams with chemistry, DMPK, toxicology, CMC, and translational functions
Translate research strategy into workplans, timelines, and go/no-go criteria; anticipate risks and propose data-driven mitigations
Coordinate and oversee in vivo studies, including scoping, CRO selection and management, dosing design, and data integrity
Mentor and provide scientific guidance to junior scientists
Analyze, interpret, and communicate data and program status to research leadership and the broader organization
Contribute to target evaluation, portfolio strategy, and new program concepts 🎯 Requirements
PhD in cancer biology, molecular/cell biology, pharmacology, biochemistry, or a related field, with 8+ years of experience, or a Master's degree with 12+ years of commensurate experience
Demonstrated record of independently leading discovery programs
Demonstrated track record advancing oncology discovery programs toward IND
Program-level or hands-on experience with targeted protein degradation, including E3 ligase biology, molecular glues and/or PROTACs, ternary complex formation, and degradation assays
Experience with antibody-drug conjugates, including target/antigen selection, internalization, linker-payload biology, DAR, bystander effect, and characterization
Ability to design and interpret in vivo oncology pharmacology studies, including xenograft/PDX, PK/PD, and efficacy
Experience managing CRO-run studies
Strong record of cross-functional collaboration across discovery and development
U.S. citizenship or authorization to work in the U.S.; employer unable to sponsor or transfer at this time
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