Senior Principal Scientist – Toxicology

Orum Therapeutics

Senior Principal Scientist driving nonclinical safety strategies for Degrader-Antibody Conjugate programs at Orum Therapeutics. Overseeing nonclinical toxicology studies and collaborating with cross-functional teams.

Posted 4/11/2026full-timeLexington • Massachusetts • 🇺🇸 United StatesSenior💰 $175,000 - $220,000 per yearWebsite

Tech Stack

Tools & technologies

DAC

About the role

Key responsibilities & impact

Design, oversee, and interpret IND-enabling nonclinical toxicology studies for DAC programs.
Serve as the nonclinical toxicology lead on assigned DAC programs, providing scientific input on nonclinical safety assessment, risk identification, and mitigation strategies.
Support clinical starting dose selection and risk assessment in collaboration with DMPK and clinical development teams.
Author and contribute to nonclinical sections of INDs and related regulatory documents.
Collaborate close with pharmacology, DMPK, pathology, bioanalytical, CMC, regulatory affairs, and clinical development teams.
Manage external CROs and consultants, ensuring scientific quality, timelines, and budget adherence.

Requirements

What you’ll need

PhD in Toxicology, Pharmacology, Biology, or a related discipline.
Minimum of 5 years of relevant industry experience in nonclinical drug development.
Demonstrated experience leading IND-enabling toxicology programs and supporting successful IND submissions.
Strong hands-on and/or strategic experience with ADC-based molecules (ADC or DAC) is required.
Experience managing CROs and working effectively in cross-functional teams.
Prefer DABT certified but not required.
Prior experience with targeted protein degradation or other emerging modalities.
Experience participating in regulatory agency interactions.

Benefits

Comp & perks

🌐 Worldwide Post a Job Affiliates ❌ Jobs You've Hidden ⭐️ Saved Jobs ✅ Applied Jobs Account Orum Therapeutics Website LinkedIn All Job Openings 11 - 50 employees Founded 2016 🧬 Biotechnology ⚕️ Healthcare Insurance 💊 Pharmaceuticals Biotechnology
Healthcare Insurance
Pharmaceuticals Orum Therapeutics is a clinical-stage biotechnology company that pioneers a novel class of antibody-drug conjugates (ADCs). The company develops innovative therapies that combine the efficacy of protein degraders with the precision of antibodies to change the landscape of disease treatment. Through its advanced TPD² cell-selective degradation technology, Orum aims to improve the efficacy, safety, and pharmacokinetics of targeted therapies. Senior Principal Scientist – Toxicology 🔥 16 minutes ago 🏢🏡 Lexington – Hybrid 💵 $175k - $220k / year ⏰ Full Time 🟠 Senior 🧬 Research Scientist Apply Now Find Hiring Managers Customize resume for this job ☆ Save ☑️ Mark as applied ❌ Hide Report problem 📋 Description
Design, oversee, and interpret IND-enabling nonclinical toxicology studies for DAC programs.
Serve as the nonclinical toxicology lead on assigned DAC programs, providing scientific input on nonclinical safety assessment, risk identification, and mitigation strategies.
Support clinical starting dose selection and risk assessment in collaboration with DMPK and clinical development teams.
Author and contribute to nonclinical sections of INDs and related regulatory documents.
Collaborate close with pharmacology, DMPK, pathology, bioanalytical, CMC, regulatory affairs, and clinical development teams.
Manage external CROs and consultants, ensuring scientific quality, timelines, and budget adherence. 🎯 Requirements
PhD in Toxicology, Pharmacology, Biology, or a related discipline.
Minimum of 5 years of relevant industry experience in nonclinical drug development.
Demonstrated experience leading IND-enabling toxicology programs and supporting successful IND submissions.
Strong hands-on and/or strategic experience with ADC-based molecules (ADC or DAC) is required.
Experience managing CROs and working effectively in cross-functional teams.
Prefer DABT certified but not required.
Prior experience with targeted protein degradation or other emerging modalities.
Experience participating in regulatory agency interactions. Apply Now 📊 Check your resume score for this job Improve your chances of getting an interview by checking your resume score before you apply. Check Resume Score 🌐 Worldwide Built by Lior Neu-ner. I'd love to hear your feedback — Get in touch via DM or support@remoterocketship.com Search Search Jobs by country Search jobs by city Search jobs by job title Search entry-level jobs Search junior-level jobs Search senior-level jobs Search jobs by tech stack Search jobs by contract type Search remote internships Search remote part-time jobs Remote jobs Anywhere in the World Companies Hiring Anywhere in the World Companies Hiring Sales People Anywhere in the World Companies Hiring Software Engineers Anywhere in the World Resources Advice Tips for finding remote jobs Interview questions and answers Resume examples Cover letter examples Post a job Affiliates Privacy policy Terms of service Job board SEO course AI Apply Copilot OpenClaw job finder Jobs by Country Remote jobs anywhere in the world (Worldwide remote jobs) Remote jobs United States Remote jobs Australia Remote jobs Brazil Remote jobs Canada Remote jobs France Remote jobs Ireland Remote jobs Germany Remote jobs Netherlands Remote jobs Spain Remote jobs UK Popular Jobs Remote data analyst jobs Remote customer support jobs Remote executive assistant jobs Remote marketing jobs Remote product designer jobs Remote product manager jobs Remote project manager jobs Remote recruiter jobs Remote sales jobs Remote software engineer jobs Jobs by Type Remote full-time jobs Remote part-time jobs Remote contract jobs Remote internship jobs Remote entry-level jobs Remote jobs with no experience required Remote junior jobs (1-3 years of experience) Digital nomad jobs Remote jobs with no degree required Freelance remote jobs Temporary remote jobs Remote jobs hiring now Stay at home mom jobs

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Hard Skills & Tools

toxicologynonclinical drug developmentIND submissionsADC-based moleculestargeted protein degradationrisk assessmentscientific inputnonclinical safety assessmentstudy designregulatory documents

Soft Skills

leadershipcollaborationcommunicationproject managementstrategic thinkingproblem-solvingteamworkbudget managementrisk identificationquality assurance

Certifications

PhD in ToxicologyPhD in PharmacologyPhD in BiologyDABT certification