Orum Therapeutics

External Research Leader – CRO

Orum Therapeutics

full-time

Posted on:

Location Type: Remote

Location: China

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Job Level

Senior

Tech Stack

DAC

About the role

  • Oversee the external development of our Degrader-Antibody Conjugate (DAC) pipeline
  • Manage high-stakes projects at CROs, specifically overseeing the synthesis of proprietary molecular glue degrader payloads and their conjugation to therapeutic antibodies
  • Proactively identify and vet CROs that offer specialized expertise in relevant in-vitro activity assays, in vivo studies, linker-payload synthesis, and complex bioconjugation
  • Support the expansion of our TPD²® (Degradation) and TPS²™ (Stabilization) platforms by identifying specialized Chinese partners capable of advanced physics-based modeling and machine learning-driven payload design
  • Drive IND-enabling studies for candidates like ORM-1153 (CD123-targeting DAC) and support ongoing clinical-stage programs
  • Navigate the "China price" ecosystem to find cost-effective, high-quality alternatives for R&D without compromising the integrity of our AnDC™ (Antibody neoDegrader Conjugate) technology

Requirements

  • PhD in Pharmacology, Biology, Organic/Medicinal Chemistry, or related field
  • Deep understanding of the E3 ubiquitin ligase pathway, linker-payload chemistry, and the nuances of antibody-mediated intracellular delivery
  • 7–10+ years in biotech/pharma with a track record of managing complex therapeutic modalities (ADCs, TPDs, or PROTACs)
  • Bilingual Fluency: Oral and written proficiency in Mandarin and English is essential for navigating local networks and communicating with global leadership
  • Global-Local Mindset: Must possess the "combo" background—international scientific training (U.S./Europe) coupled with significant operational experience within the Chinese regulatory and CRO landscape.
Benefits
  • Full home-office setup stipend to facilitate seamless virtual collaboration with our global R&D leadership
Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools
E3 ubiquitin ligase pathwaylinker-payload chemistryantibody-mediated intracellular deliverytherapeutic modalitiesADCsTPDsPROTACsadvanced physics-based modelingmachine learning-driven payload designIND-enabling studies
Soft Skills
bilingual fluencycommunicationglobal-local mindsetproject managementstrategic thinkingproblem-solvinginterpersonal skillsleadershipnegotiationnetworking
Certifications
PhD in PharmacologyPhD in BiologyPhD in Organic ChemistryPhD in Medicinal Chemistry