Associate Director, Computational Biology – Bioinformatics

Obsidian Therapeutics

Associate Director leading computational biology and bioinformatics for clinical cell therapy development at Obsidian Therapeutics. Overseeing analytical strategy and collaborating across teams in a hybrid role.

Posted 6/26/2026full-timeBedford • Massachusetts • 🇺🇸 United StatesSenior💰 $189,000 - $241,500 per yearWebsite

Tech Stack

Tools & technologies

AWSAzureCloudDockerPythonShell ScriptingUnix

About the role

Key responsibilities & impact

Lead and champion computational efforts associated with the Clinical, translational, discovery and research program efforts including analytical support for biomarker discovery and analysis to support translational and research activities.
Identify and implement computational methodologies and datasets needed to advance discovery and programmatic activities.
Oversee the execution of analyses for routine assays that use sequencing, array and biological data by running, maintaining, and updating analytical pipelines.
Lead the strategic efforts related to data and analysis quality using quality-control measures, and collaborate on establishing data management practices.
Communicate analysis results and interpretations with key stakeholders using high-quality reports in a timely manner.
Support ad hoc statistical design and analyses for research projects and programs.
Exercise standard code-management practices, while maintaining analytical documentation and study reports in Electronic Notebook entries.
Collaborate effectively across Obsidian organization to support ongoing research projects and clinical program development by contributing analytical insights, requirements, workflows and presenting internally to project teams, management, and scientific teams.

Requirements

What you’ll need

PhD in Computational Biology/Bioinformatics, Bioengineering, Computer Science or a related field with 3+ years of experience in industry, OR a MS degree in one of the above areas with 8+ years of relevant work experience.
Proficiency with commonly used programming languages for bioinformatics analysis, such as Python, R, and shell scripting.
Proficiency with NGS data analysis tools and pipelines (QC, alignment, secondary data analysis, enrichment analysis).
Proficiency with Unix-based systems, source version control (e.g. Git) and cloud computing environments and tools (e.g. AWS, Azure, docker).
Proficient in biostatical methods.
Demonstrated success in leading the computational function in a matrixed, cross-disciplinary organization.
Highly collaborative working style and ability to adapt in a fast paced, rapidly developing environment.
Ability to work with general direction to meet objectives and timelines, adapting to changes and priorities to fulfill our mission

Benefits

Comp & perks

Competitive salary and benefits
Annual incentive bonus as a percentage of actual base salary
Long-term incentives in the form of employee stock options
Comprehensive medical, dental, and vision coverage
Company contributions to health savings and retirement accounts
Ample paid time off
Access to wellness programs
Rich career growth opportunities

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Hard Skills & Tools

computational biologybioinformaticsbioengineeringcomputer sciencePythonRshell scriptingNGS data analysisbiostatistical methodsanalytical pipelines

Soft Skills

collaborative working styleadaptabilitycommunicationleadershipproblem-solvingtime managementattention to detailstrategic thinkingcross-disciplinary collaborationability to work under direction