Senior Director, IT

Nautilus Biotechnology

Senior Director of IT for Nautilus improving health through precision medicine. Overseeing IT strategy, security, and budget management while leading teams.

Posted 5/22/2026full-timeSan Carlos • California • 🇺🇸 United StatesSenior💰 $193,000 - $277,000 per yearWebsite

Tech Stack

Tools & technologies

AWSAzureCloudCyber SecurityERP

About the role

Key responsibilities & impact

Develop and implement IT strategies that align with organizational goals.
Combine strategic leadership with practical, day-to-day technical engagement to drive reliable operations across infrastructure, hardware, networking, systems management, ensuring reliability, scalability, and performance.
Ensure data security, compliance, incidence response and disaster recovery protocols are in place.
Oversee and own IT budgets, vendor relationships, and procurement processes to ensure cost-effective and value-driven technology investments.
Provide regular updates to senior leadership on IT budget performance, risk posture, cybersecurity initiatives, and strategic priorities.
Identify and implement emerging technologies to improve business processes.
Implement AI strategy for increased organizational efficiency, decision-making, and operational outcomes.
Collaborate with software, operations, and legal teams to define and enforce enterprise-wide data governance policies and practices.
Partner with engineering, operations, finance, and software teams to enable technology-driven commercialization efforts.
Drive the selection, integration and management of business systems (ERP, HRIS, PLM, CRM, etc.) crucial to operations and commercialization efforts.
Play an integral role in product definition, requirements specification and execution.
Champion DevOps practices driving infrastructure-as-code (IaC), automation, continuous integration and continuous delivery (CI/CD) pipelines.
Inspire, mentor, and grow high-performing IT teams, fostering a culture of innovation, accountability, and cross-functional collaboration.
Set and communicate clear team priorities, ensuring alignment with company strategy and responsiveness to evolving business needs.
Build and reinforce scalable, actionable processes that empower teams to make informed decisions and deliver consistent results.
Foster collaboration between development and operations teams to streamline deployment processes and improve system reliability.
Navigate and lead teams through change, leveraging competitive insights and innovative thinking to adapt and thrive in dynamic environments.

Requirements

What you’ll need

Bachelor’s degree in information technology, information systems, computer science or a related field.
12+ years of IT experience, with 10+ years in a managerial role.
Expertise in cloud computing (preferably AWS and Azure), network design and infrastructure, and enterprise software.
Experience managing DevOps, driving IaC, automation, CI/CD pipelines, and collaboration between development and operations teams.
Experience deploying security and SaaS tools across organizations.
Proven experience deploying commercial products.
Deep understanding of IT architecture and cybersecurity.
Strong familiarity with software development practices.
Strong leadership and project management skills.
Experience with regulatory standards across data privacy, security, financial data management (GDPR, CCPA, HIPAA, SOX, ISO27001, etc.).
Requires bimonthly travel between office locations.

Benefits

Comp & perks

medical, vision, and dental insurance
group and supplemental life insurance
401k retirement plan
responsible paid time off
parental leave
competitive options grant at the time of hire (with potential for additional grants)

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

cloud computingAWSAzurenetwork designinfrastructureDevOpsinfrastructure-as-codeautomationCI/CDcybersecurity

Soft Skills

leadershipproject managementcollaborationmentoringstrategic thinkingcommunicationinnovationaccountabilityadaptabilityteam building