Senior Medical Director, Translational Medicine – Early Clinical Development

Madrigal Pharmaceuticals

Senior physician-scientist leading early clinical and translational development for Madrigal’s MASH therapeutics. Shaping biomarker strategy, trials, and decisions for metabolic liver and cardiometabolic programs.

Posted 8/11/2026full-timeConshohocken • Massachusetts, Pennsylvania • 🇺🇸 United StatesSenior💰 $259,000 - $317,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in leading early-phase clinical studies, with a strong focus on translational medicine and biomarker-driven development. Capable of providing medical oversight and strategic direction while effectively communicating complex concepts to diverse stakeholders.

Highest-signal resume keywords

MD With Clinical Training15+ Years Industry ExperienceLeadership Of Early-Phase TrialsTranslational Medicine ExpertiseRegulatory Agency Interaction

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Clinical DevelopmentProtocol DesignSafety MonitoringDose Decision-MakingBiomarker AnalysisPharmacokineticsPharmacodynamicsData IntegrationClinical OversightMechanistic Input

Soft Skills

Excellent CommunicationInfluencing Without AuthorityMentoringRelationship BuildingCross-Functional Collaboration

Industry Keywords

Early Phase StudiesFirst-In-Human TrialsProof-Of-Concept TrialsMetabolic Liver DiseaseCardiometabolic DiseaseBiospecimen BankingTranslational StrategiesClinical Biomarker PlansGovernance ForumsScientific Conferences

About the role

Key responsibilities & impact

Serve as global medical lead and medical monitor for early phase studies, including first-in-human, proof-of-concept, mechanistic, and indication-expansion trials
Lead study concepts and protocol design, including patient populations, clinical and biomarker endpoints, and mechanistic sub-studies
Provide medical oversight, including eligibility review, safety monitoring, dose decision-making, and emerging-data interpretation
Partner with Clinical Operations and CROs on high-quality execution, timely data delivery, and inspection-readiness
Define and own translational strategies from preclinical through late-stage development
Integrate pharmacokinetic, pharmacodynamic, biomarker, imaging, and clinical outcome data to inform dose/regimen selection
Oversee clinical biomarker plans and biospecimen banking and downstream analysis
Chair or co-chair early asset teams and translational working groups
Partner cross-functionally on integrated development strategy
Provide clinical and mechanistic input into development, regulatory, publication, and presentation documents
Present program and mechanistic work to governance forums, Executive Team, Board, and external scientific audiences
Build relationships with external experts and lead or co-lead academic and consortium collaborations
Represent Madrigal at scientific and medical conferences
Mentor junior physicians and PhD scientists
Help evolve the Translational Medicine operating model and interfaces with Research and Clinical Development

Requirements

What you’ll need

MD with clinical training in a relevant specialty, such as hepatology, gastroenterology, endocrinology, cardiology, or internal medicine, or equivalent
15+ years of relevant industry experience in clinical development
Demonstrable leadership of early-phase interventional trials
Strong track record in translational medicine and biomarker-driven development
Experience in metabolic liver or cardiometabolic disease strongly preferred
Experience interacting with regulatory agencies on early development and biomarker topics highly desirable
Ability to lead cross-functional teams, influence without authority, and operate effectively in a growing, evolving organization
Excellent communication skills and ability to articulate complex mechanistic concepts to researchers, clinicians, executives, and board members

Benefits

Comp & perks

Base salary
Bonus
Equity
Flexible paid time off
Medical insurance
Dental insurance
Vision insurance
Life/disability insurance
401(k) offerings, including traditional, Roth, and employer match
Supplemental life insurance
Legal services
Mental health benefits through the Employee Assistance Program for employees and their family
Reasonable accommodations throughout the hiring process