Vice President, Clinical Operations

Lexeo Therapeutics

Lead Clinical Operations at Lexeo Therapeutics, overseeing global clinical trials and strategy. Collaborate across internal and external teams to ensure trial success and compliance.

Posted 5/23/2026full-timeNew York City • New York • 🇺🇸 United StatesLead💰 $300,000 - $350,000 per yearWebsite

Tech Stack

Tools & technologies

Google Cloud Platform

About the role

Key responsibilities & impact

Collaborate with Lexeo CMO, R&D leadership, Weill Cornell research staff, Lexeo clinical, quality, and regulatory colleagues, CRO partners and other vendors to conduct clinical trials that meet corporate goals
Evaluate and develop optimal outsourcing model for implementation of trials including selection of CROs and other vendors/ external partners. Oversee development of requests for proposals, negotiate and approve contracts and work orders, and review invoices prior to submission for approval
Develop, maintain, and report on program budgets, including long-range forecasting, in support of Lexeo’s financial goals
Monitor study-specific timelines, key deliverables, and implement strategies to optimize the efficiency of trial conduct
Provide oversight of the CROs to avoid issues or rapidly adapt to challenges of feasibility/start up, slow recruitment, resourcing, site management, etc.

Requirements

What you’ll need

Advanced degree preferred and 10+ years of experience in the pharmaceutical or biotech industry within clinical operations and trial management
Experience leading global clinical trials; rare disease/gene therapy trial experience preferred
Thorough knowledge of development program management from IND- through NDA/BLA, including inspection readiness
Extensive experience in CRO/ vendor selection and oversight, budget projection and management, establishing clear milestones, ensuring high-quality data delivery and report generation
Advanced working knowledge of all relevant guidelines, including ICH, GCP, FDA
Experience working in a fast-paced environment
Excellent communication skills and ability to influence across multiple functions

Benefits

Comp & perks

🌐 Worldwide ❌ Jobs You've Hidden ⭐️ Saved Jobs ✅ Applied Jobs ✉️ Email Alerts 👤 Account Lexeo Therapeutics Website LinkedIn All Job Openings 11 - 50 employees 💰 Corporate Round on 2023-08 Based in New York City, Lexeo Therapeutics is a clinical-stage genetic medicines company dedicated to transforming healthcare by applying pioneering science to fundamentally change how disease is treated. Building on groundbreaking research from Weill Cornell Medicine and the University of California San Diego, Lexeo partners with preeminent institutions on the cutting edge of gene therapy research. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of cardiovascular and APOE4 associated Alzheimer's disease programs, and is led by pioneers and experts with decades of collective experience in genetic medicines, rare disease drug development, manufacturing and commercialization. Vice President, Clinical Operations 🔥 50 minutes ago 🏢🏡 New York City – Hybrid 💵 $300k - $350k / year ⏰ Full Time 🔴 Lead 🏥 Clinical Operations 🦅 H1B Visa Sponsor Apply Now Find Hiring Managers Customize resume + cover letter Report problem ☆ Save ☑️ Mark as applied ❌ Hide 📋 Description
Collaborate with Lexeo CMO, R&D leadership, Weill Cornell research staff, Lexeo clinical, quality, and regulatory colleagues, CRO partners and other vendors to conduct clinical trials that meet corporate goals
Evaluate and develop optimal outsourcing model for implementation of trials including selection of CROs and other vendors/ external partners. Oversee development of requests for proposals, negotiate and approve contracts and work orders, and review invoices prior to submission for approval
Develop, maintain, and report on program budgets, including long-range forecasting, in support of Lexeo’s financial goals
Monitor study-specific timelines, key deliverables, and implement strategies to optimize the efficiency of trial conduct
Provide oversight of the CROs to avoid issues or rapidly adapt to challenges of feasibility/start up, slow recruitment, resourcing, site management, etc. 🎯 Requirements
Advanced degree preferred and 10+ years of experience in the pharmaceutical or biotech industry within clinical operations and trial management
Experience leading global clinical trials; rare disease/gene therapy trial experience preferred
Thorough knowledge of development program management from IND- through NDA/BLA, including inspection readiness
Extensive experience in CRO/ vendor selection and oversight, budget projection and management, establishing clear milestones, ensuring high-quality data delivery and report generation
Advanced working knowledge of all relevant guidelines, including ICH, GCP, FDA
Experience working in a fast-paced environment
Excellent communication skills and ability to influence across multiple functions Apply Now 📊 Check your resume score for this job Improve your chances of getting an interview by checking your resume score before you apply. Check Resume Score 🌐 Worldwide Built by Lior Neu-ner. I'd love to hear your feedback — Get in touch via DM or support@remoterocketship.com Search Search Jobs by country Search jobs by city Search jobs by job title Search entry-level jobs Search junior-level jobs Search senior-level jobs Search jobs by tech stack Search jobs by contract type Search remote internships Search remote part-time jobs Remote jobs Anywhere in the World Companies Hiring Anywhere in the World Companies Hiring Sales People Anywhere in the World Companies Hiring Software Engineers Anywhere in the World Resources Advice Tips for finding remote jobs Interview questions and answers Resume examples Cover letter examples Post a job Affiliates Privacy policy Terms of service Job board SEO course AI Apply Copilot OpenClaw job finder Jobs by Country Remote jobs anywhere in the world (Worldwide remote jobs) Remote jobs United States Remote jobs Australia Remote jobs Brazil Remote jobs Canada Remote jobs France Remote jobs Ireland Remote jobs Germany Remote jobs Netherlands Remote jobs Spain Remote jobs UK Popular Jobs Remote data analyst jobs Remote customer support jobs Remote executive assistant jobs Remote marketing jobs Remote product designer jobs Remote product manager jobs Remote project manager jobs Remote recruiter jobs Remote sales jobs Remote software engineer jobs Jobs by Type Remote full-time jobs Remote part-time jobs Remote contract jobs Remote internship jobs Remote entry-level jobs Remote jobs with no experience required Remote junior jobs (1-3 years of experience) Digital nomad jobs Remote jobs with no degree required Freelance remote jobs Temporary remote jobs Remote jobs hiring now Stay at home mom jobs

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Hard Skills & Tools

clinical trial managementbudget managementprogram managementCRO selectionvendor oversightdata deliveryreport generationmilestone establishmentIND to NDA/BLA knowledgeinspection readiness

Soft Skills

communication skillsinfluencing skillscollaborationproblem-solvingadaptabilityleadershiporganizational skillsstrategic thinkingnegotiation skillstime management