Clinical Trial Manager – Senior

Lexeo Therapeutics

Clinical Trial Manager/Senior Clinical Trial Manager leading execution of clinical studies at Lexeo Therapeutics. Collaborating with cross-functional teams and ensuring regulatory compliance throughout clinical trial phases.

Posted 5/21/2026full-timeNew York City • New York • 🇺🇸 United StatesSenior💰 $143,350 - $180,000 per yearWebsite

Tech Stack

Tools & technologies

Google Cloud Platform

About the role

Key responsibilities & impact

Lead day-to-day management of clinical studies to ensure delivery against timelines, budget, and quality expectations
Drive study milestones and proactively identify and mitigate risks
Oversee CROs, laboratories, and vendors to ensure performance aligns with scope, timelines, and budget
Manage vendor relationships, including scope changes, issue resolution, and ongoing performance oversight
Partner with internal stakeholders across Clinical, Regulatory, Data Management, and other functions
Serve as a central operational lead to ensure alignment and efficient study execution
Contribute to study planning, including timelines, resource plans, budgets, and risk management strategies
Provide operational input into protocol development, feasibility, and study design
Act as the primary sponsor contact for study sites
Oversee site startup and ongoing site management activities
Ensure proper sample handling, data flow, and protocol adherence
Ensure compliance with ICH/GCP, FDA regulations, and company SOPs
Maintain inspection readiness and support audits and regulatory inspections
Ensure completeness and integrity of the Trial Master File (TMF)
Author and review study plans, operational documents, and training materials
Communicate study status, risks, and mitigation plans to stakeholders
Contribute to process improvements and operational excellence initiatives
(Sr. CTM) Lead cross-study or departmental initiatives

Requirements

What you’ll need

Bachelor’s degree in life sciences or a related field; advanced degree preferred
Clinical Trial Manager: minimum 7 years of clinical research experience; 4 years with advanced degree
Senior Clinical Trial Manager: experience leading complex or global studies, worked on a clinical study from concept to database lock
Strong knowledge of ICH/GCP, FDA regulations, and clinical trial operations
Experience managing CROs and other external vendors
Proven ability to manage timelines, budgets, and multiple priorities
Excellent communication, problem-solving, and leadership skills
Demonstrated leadership skills
Ability to work effectively in a fast-paced, collaborative environment
Ability to travel to sites as needed, including international travel
Ability to work Eastern Time Zone and travel to New York HQ quarterly

Benefits

Comp & perks

🌐 Worldwide ❌ Jobs You've Hidden ⭐️ Saved Jobs ✅ Applied Jobs ✉️ Email Alerts 👤 Account Lexeo Therapeutics Website LinkedIn All Job Openings 11 - 50 employees 💰 Corporate Round on 2023-08 Based in New York City, Lexeo Therapeutics is a clinical-stage genetic medicines company dedicated to transforming healthcare by applying pioneering science to fundamentally change how disease is treated. Building on groundbreaking research from Weill Cornell Medicine and the University of California San Diego, Lexeo partners with preeminent institutions on the cutting edge of gene therapy research. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of cardiovascular and APOE4 associated Alzheimer's disease programs, and is led by pioneers and experts with decades of collective experience in genetic medicines, rare disease drug development, manufacturing and commercialization. Clinical Trial Manager – Senior 🔥 51 minutes ago 🏢🏡 New York City – Hybrid 💵 $143.3k - $180k / year ⏰ Full Time 🟠 Senior 🧪 Clinical Research 🦅 H1B Visa Sponsor Apply Now Find Hiring Managers Customize resume + cover letter Report problem ☆ Save ☑️ Mark as applied ❌ Hide 📋 Description
Lead day-to-day management of clinical studies to ensure delivery against timelines, budget, and quality expectations
Drive study milestones and proactively identify and mitigate risks
Oversee CROs, laboratories, and vendors to ensure performance aligns with scope, timelines, and budget
Manage vendor relationships, including scope changes, issue resolution, and ongoing performance oversight
Partner with internal stakeholders across Clinical, Regulatory, Data Management, and other functions
Serve as a central operational lead to ensure alignment and efficient study execution
Contribute to study planning, including timelines, resource plans, budgets, and risk management strategies
Provide operational input into protocol development, feasibility, and study design
Act as the primary sponsor contact for study sites
Oversee site startup and ongoing site management activities
Ensure proper sample handling, data flow, and protocol adherence
Ensure compliance with ICH/GCP, FDA regulations, and company SOPs
Maintain inspection readiness and support audits and regulatory inspections
Ensure completeness and integrity of the Trial Master File (TMF)
Author and review study plans, operational documents, and training materials
Communicate study status, risks, and mitigation plans to stakeholders
Contribute to process improvements and operational excellence initiatives
(Sr. CTM) Lead cross-study or departmental initiatives 🎯 Requirements
Bachelor’s degree in life sciences or a related field; advanced degree preferred
Clinical Trial Manager: minimum 7 years of clinical research experience; 4 years with advanced degree
Senior Clinical Trial Manager: experience leading complex or global studies, worked on a clinical study from concept to database lock
Strong knowledge of ICH/GCP, FDA regulations, and clinical trial operations
Experience managing CROs and other external vendors
Proven ability to manage timelines, budgets, and multiple priorities
Excellent communication, problem-solving, and leadership skills
Demonstrated leadership skills
Ability to work effectively in a fast-paced, collaborative environment
Ability to travel to sites as needed, including international travel
Ability to work Eastern Time Zone and travel to New York HQ quarterly Apply Now 📊 Check your resume score for this job Improve your chances of getting an interview by checking your resume score before you apply. Check Resume Score 🌐 Worldwide Built by Lior Neu-ner. I'd love to hear your feedback — Get in touch via DM or support@remoterocketship.com Search Search Jobs by country Search jobs by city Search jobs by job title Search entry-level jobs Search junior-level jobs Search senior-level jobs Search jobs by tech stack Search jobs by contract type Search remote internships Search remote part-time jobs Remote jobs Anywhere in the World Companies Hiring Anywhere in the World Companies Hiring Sales People Anywhere in the World Companies Hiring Software Engineers Anywhere in the World Resources Advice Tips for finding remote jobs Interview questions and answers Resume examples Cover letter examples Post a job Affiliates Privacy policy Terms of service Job board SEO course AI Apply Copilot OpenClaw job finder Jobs by Country Remote jobs anywhere in the world (Worldwide remote jobs) Remote jobs United States Remote jobs Australia Remote jobs Brazil Remote jobs Canada Remote jobs France Remote jobs Ireland Remote jobs Germany Remote jobs Netherlands Remote jobs Spain Remote jobs UK Popular Jobs Remote data analyst jobs Remote customer support jobs Remote executive assistant jobs Remote marketing jobs Remote product designer jobs Remote product manager jobs Remote project manager jobs Remote recruiter jobs Remote sales jobs Remote software engineer jobs Jobs by Type Remote full-time jobs Remote part-time jobs Remote contract jobs Remote internship jobs Remote entry-level jobs Remote jobs with no experience required Remote junior jobs (1-3 years of experience) Digital nomad jobs Remote jobs with no degree required Freelance remote jobs Temporary remote jobs Remote jobs hiring now Stay at home mom jobs

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Hard Skills & Tools

clinical researchclinical trial managementstudy designrisk managementprotocol developmentdata managementbudget managementvendor managementsample handlingTrial Master File (TMF)

Soft Skills

leadershipcommunicationproblem-solvingcollaborationorganizational skillstime managementstakeholder managementadaptabilityinitiativeprocess improvement