Scientist/Sr. Scientist, Oligo Biology – In Vitro

Korsana Biosciences

Scientist/Sr. Scientist managing in vitro screening and optimizing oligonucleotides for Korsana Biosciences.

Posted 7/15/2026full-timeRemote • California • 🇺🇸 United StatesSenior💰 $115,000 - $175,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Expertise in designing and optimizing siRNAs, ASOs, and other nucleotide modalities, with a strong focus on oligonucleotide therapeutic development and innovative delivery technologies. Proficient in managing CROs and collaborating with multidisciplinary teams to ensure high-quality project execution and effective communication of scientific results.

Highest-signal resume keywords

Ph.D. In BiologySiRNA Design PrinciplesASO Design PrinciplesOligonucleotide Delivery TechnologiesMammalian Cell Culture

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Applicant Tracking System Keywords

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Hard Skills

Experimental DesignData ReviewTechnical OversightStructure-Activity Relationships (SAR)Oligonucleotide Potency EnhancementChemical Modification StrategiesTransfection MethodologiesTimeline ManagementProactive TroubleshootingTechnical Documentation

Soft Skills

CollaborationCommunicationProblem-Solving

Tools & Technologies

Electronic Lab Notebooks (ELNs)GalNAc ConjugatesLipid ConjugatesPeptide/Antibody-Oligonucleotide Conjugates

Industry Keywords

Oligonucleotide Therapeutic DevelopmentIn Vitro ScreeningIn Vivo ScreeningEmerging TechnologiesScientific Literature Evaluation

About the role

Key responsibilities & impact

Design molecular and cellular biology experiments in close collaboration with internal bioinformatics and chemistry teams to support robust in vitro and in vivo screening campaigns.
Manage external CROs, including experimental design, priority setting, technical oversight, data review, timeline management, and proactive troubleshooting to ensure high-quality, timely project execution.
Design and optimize siRNAs, ASOs, PMOs, and other novel nucleotide modalities to enhance therapeutic profiles.
Generate and interpret structure-activity relationships (SAR) to guide lead optimization and candidate selection.
Maintain thorough technical documentation using Electronic Lab Notebooks (ELNs) and effectively communicate experimental strategies, results, and recommendations to multidisciplinary scientific audiences.
Actively evaluate emerging technologies and scientific literature to identify innovative approaches that enhance oligonucleotide potency, extrahepatic delivery, durability, and safety.

Requirements

What you’ll need

Ph.D. in biology, pharmaceutical sciences, or related discipline with 0-6 years of relevant industry experience, OR M.S. with 2-8 years of industry experience in oligonucleotide therapeutic development.
Deep understanding of siRNA and ASO design principles, cellular mechanisms of action, and chemical modification strategies.
Familiarity with state-of-the-art oligonucleotide delivery technologies, including GalNAc conjugates, lipid conjugates, peptide/antibody-oligonucleotide conjugates (AOCs), or other targeted delivery methods.
Hands-on experience with mammalian cell culture, diverse transfection methodologies.

Benefits

Comp & perks

Eligible for target annual bonus
Equity-based compensation
Participation in the company’s benefit programs