Principal Scientist, Immunology

Jade Biosciences

Principal Scientist leading immunology-driven research for Jade Biosciences' pipeline. Integrating insights to enhance clinical development for autoimmune therapies.

Posted 6/26/2026full-timeRemote • California, Washington • 🇺🇸 United StatesLead💰 $175,000 - $190,000 per yearWebsite

About the role

Key responsibilities & impact

Lead immunology-driven research strategy across pipeline programs to support scientific narrative and indication assessment, integrating literature, experimental data, and translational insights
Design and oversee mechanism-of-action studies to elucidate target biology, pathway modulation, and disease relevance across in vitro, ex vivo, and in vivo models, executed in partnership with CROs
Partner closely with Translational Medicine, Clinical Pharmacology, and Nonclinical teams to ensure alignment of preclinical findings with clinical strategy
Generate and interpret complex datasets (e.g., cellular immunology, cytokine profiling, pathway analysis), ensuring rigorous and hypothesis-driven conclusions
Identify and validate new targets and pathways for pipeline expansion, leveraging deep understanding of disease biology, emerging science, and internal platform capabilities
Evaluate and prioritize new indication opportunities, integrating mechanistic rationale, competitive landscape, and translational feasibility
Support external collaborations and CRO activities, providing scientific direction and technical oversight to ensure high-quality data generation
Author and contribute to scientific documents, including study reports, regulatory sections (e.g., IND-enabling rationale), presentations, and publications
Present findings to internal governance teams and external scientific forums
Stay current with advances in immunology, inflammation, and translational science, applying new insights to strengthen program and pipeline strategy

Requirements

What you’ll need

PhD in Immunology or related field with 8–12+ years of relevant industry experience is required
Deep expertise in immunology and disease biology, particularly in autoimmune and inflammatory disease mechanisms
Strong understanding of drug development, including how preclinical and translational data inform clinical strategy
Experience with immunological assays and platforms (e.g., flow cytometry, ELISA/MSD, cytokine panels, cellular assays); familiarity with advanced platforms (e.g., single-cell, proteomics) is a plus
Experience working in cross-functional teams (e.g., Translational Medicine, Clinical, Nonclinical)
Strong written and verbal communication skills, with a track record of scientific publications and presentations
Ability to operate independently while contributing to a collaborative, fast-paced biotech environment.

Benefits

Comp & perks

🌐 Worldwide ❌ Jobs You've Hidden ⭐️ Saved Jobs ✅ Applied Jobs ✉️ Email Alerts 👤 Account Jade Biosciences Website LinkedIn All Job Openings 11 - 50 employees Founded 2024 🧬 Biotechnology 💊 Pharmaceuticals Biotechnology
Pharmaceuticals Jade Biosciences is a clinical-stage biotechnology company developing potentially best-in-class therapies aimed at transforming the standard of care for autoimmune diseases. Its lead candidate, JADE101, is an antibody designed to inhibit the cytokine APRIL (A PRoliferation-Inducing Ligand) and is being developed for the treatment of immunoglobulin A nephropathy (IgAN). The company builds its pipeline from discovery-stage assets licensed from Paragon Therapeutics and is focused on advancing clinical programs to deliver new treatments for patients with autoimmune conditions. Principal Scientist, Immunology 🔥 2 minutes ago 🏄 California, Washington – Remote 💵 $175k - $190k / year ⏰ Full Time 🔴 Lead 🧬 Research Scientist Apply Now Find Hiring Managers Customize resume + cover letter Report problem ☆ Save ☑️ Mark as applied ❌ Hide 📋 Description
Lead immunology-driven research strategy across pipeline programs to support scientific narrative and indication assessment, integrating literature, experimental data, and translational insights
Design and oversee mechanism-of-action studies to elucidate target biology, pathway modulation, and disease relevance across in vitro, ex vivo, and in vivo models, executed in partnership with CROs
Partner closely with Translational Medicine, Clinical Pharmacology, and Nonclinical teams to ensure alignment of preclinical findings with clinical strategy
Generate and interpret complex datasets (e.g., cellular immunology, cytokine profiling, pathway analysis), ensuring rigorous and hypothesis-driven conclusions
Identify and validate new targets and pathways for pipeline expansion, leveraging deep understanding of disease biology, emerging science, and internal platform capabilities
Evaluate and prioritize new indication opportunities, integrating mechanistic rationale, competitive landscape, and translational feasibility
Support external collaborations and CRO activities, providing scientific direction and technical oversight to ensure high-quality data generation
Author and contribute to scientific documents, including study reports, regulatory sections (e.g., IND-enabling rationale), presentations, and publications
Present findings to internal governance teams and external scientific forums
Stay current with advances in immunology, inflammation, and translational science, applying new insights to strengthen program and pipeline strategy 🎯 Requirements
PhD in Immunology or related field with 8–12+ years of relevant industry experience is required
Deep expertise in immunology and disease biology, particularly in autoimmune and inflammatory disease mechanisms
Strong understanding of drug development, including how preclinical and translational data inform clinical strategy
Experience with immunological assays and platforms (e.g., flow cytometry, ELISA/MSD, cytokine panels, cellular assays); familiarity with advanced platforms (e.g., single-cell, proteomics) is a plus
Experience working in cross-functional teams (e.g., Translational Medicine, Clinical, Nonclinical)
Strong written and verbal communication skills, with a track record of scientific publications and presentations
Ability to operate independently while contributing to a collaborative, fast-paced biotech environment. Apply Now 📊 Check your resume score for this job Improve your chances of getting an interview by checking your resume score before you apply. Check Resume Score Similar Jobs Principal Decision Scientist, Applied Optimization and Simulation 🕒 Yesterday Aimpoint Digital 51 - 200 🤖 Artificial Intelligence Website LinkedIn All Job Openings Principal Decision Scientist at Aimpoint Digital enabling clients with data-driven solutions. Leading data science projects and providing technical leadership across teams. 🇺🇸 United States – Remote ⏰ Full Time 🔴 Lead 🧬 Research Scientist 🦅 H1B Visa Sponsor Staff Applied ML Scientist 🕒 2 days ago SentiLink 51 - 200 🔐 Security 💳 Fintech 💸 Finance Website LinkedIn All Job Openings Staff Applied ML Scientist developing fraud detection models and financial risk products for SentiLink. Focused on research, model development, and cross-team collaboration for fraud verification. 🇺🇸 United States – Remote 💵 $220k - $260k / year 💰 $70M Series B on 2021-08 ⏰ Full Time 🔴 Lead 🧬 Research Scientist 🦅 H1B Visa Sponsor Study Monitor – Principal Scientist, Translational Medicine, Preclinical Safety 🕒 June 19 Novartis 10,000+ employees 💊 Pharmaceuticals 🧬 Biotechnology ⚕️ Healthcare Insurance Website LinkedIn All Job Openings Scientific Study Monitor overseeing non-clinical research activities for multiple projects in preclinical safety at Novartis. Focused on ensuring compliance with GLP regulations and protocols in collaboration with CROs. 🇺🇸 United States – Remote 💵 $119.7k - $222.3k / year ⏰ Full Time 🔴 Lead 🧬 Research Scientist 🦅 H1B Visa Sponsor Principal Scientist, Translational Medicine, Preclinical Safety 🕒 June 18 Kerr Dental 1001 - 5000 ⚕️ Healthcare Insurance 🔬 Science 🧘 Wellness Website LinkedIn All Job Openings Scientific Study Monitor in Translational Medicine overseeing non-clinical research activities in preclinical safety. Leading projects and ensuring compliance to GLP regulations and international standards. 🇺🇸 United States – Remote 💵 $119.7k - $222.3k / year 💰 Debt Financing on 2005-12 ⏰ Full Time 🔴 Lead 🧬 Research Scientist Law Enforcement Policy Research Scientist 🕒 June 18 The Ohio State University, Main Campus 1 - 10 📚 Education Website LinkedIn All Job Openings Research Scientist focusing on police supervision and public safety research within Ohio State's Glenn College. Leading CAPS initiative for evidence-based resources and training. 🇺🇸 United States – Remote ⏰ Full Time 🟠 Senior 🔴 Lead 🧬 Research Scientist View More Research Scientist Jobs 🌐 Worldwide Built by Lior Neu-ner. I'd love to hear your feedback — Get in touch via DM or support@remoterocketship.com Search Search Jobs by country Search jobs by city Search jobs by job title Search entry-level jobs Search junior-level jobs Search senior-level jobs Search jobs by tech stack Search jobs by contract type Search remote internships Search remote part-time jobs Remote jobs Anywhere in the World Companies Hiring Anywhere in the World Companies Hiring Sales People Anywhere in the World Companies Hiring Software Engineers Anywhere in the World Resources Advice Tips for finding remote jobs Interview questions and answers Resume examples Cover letter examples Post a job Affiliates Privacy policy Terms of service Job board SEO course AI Apply Copilot OpenClaw job finder Jobs by Country Remote jobs anywhere in the world (Worldwide remote jobs) Remote jobs United States Remote jobs Australia Remote jobs Brazil Remote jobs Canada Remote jobs France Remote jobs Ireland Remote jobs Germany Remote jobs Netherlands Remote jobs Spain Remote jobs UK Popular Jobs Remote data analyst jobs Remote customer support jobs Remote executive assistant jobs Remote marketing jobs Remote product designer jobs Remote product manager jobs Remote project manager jobs Remote recruiter jobs Remote sales jobs Remote software engineer jobs Jobs by Type Remote full-time jobs Remote part-time jobs Remote contract jobs Remote internship jobs Remote entry-level jobs Remote jobs with no experience required Remote junior jobs (1-3 years of experience) Digital nomad jobs Remote jobs with no degree required Freelance remote jobs Temporary remote jobs Remote jobs hiring now Stay at home mom jobs

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Hard Skills & Tools

immunologydisease biologydrug developmentimmunological assaysflow cytometryELISAcytokine panelscellular assayssingle-cell analysisproteomics

Soft Skills

strong written communicationstrong verbal communicationcollaborationindependencefast-paced environment

Certifications

PhD in Immunology