Scientist, Analytical Operations
Gilead Sciences
full-time
Posted on:
Location Type: Office
Location: Oceanside • California • 🇺🇸 United States
Visit company websiteSalary
💰 $133,195 - $189,640 per year
Job Level
Mid-LevelSenior
About the role
- Develop and optimize N-glycan analysis workflows (HILIC-FLD, LC-MS, CE-LIF etc.), including sialic acid, NGNA, α‑Gal characterization and quantitation analysis.
- Drive advanced structural elucidation of N-glycans using LC‑MS/MS, exoglycosidase sequencing, linkage analysis, monosaccharide analysis, and orthogonal structural tools.
- Perform intact and subunit mass spectrometry, as well as glycopeptide mapping, to define glycan occupancy, site-specific heterogeneity, and structural impacts on the protein backbone.
- Integrate glycan structural information with functional outcomes such as Fc receptor binding, Fc silencing/attenuation, CH2 stability, higher-order structure changes, aggregation, and immunogenicity risk.
- Support glycosylation pCQA/CQA assessments, providing mechanism interpretation, structure-function justifications, and cross-program scientific guidance.
- Support glycan-driven structural differences assessment in comparability studies.
- Author technical reports, glycan characterization summaries, method development documentation, and regulatory submission content.
- Continuously evaluate and implement emerging innovations in glycomics, glycoproteomics, and computational structure–function modeling.
Requirements
- BS with +6 years of relevant experience in Analytical Chemistry, Glycobiology, Biochemistry, Biophysics, or related field OR MS with +4 years of relevant experience in Analytical Chemistry, Glycobiology, Biochemistry, Biophysics, or related field OR PhD with 0 years of relevant experience in Analytical Chemistry, Glycobiology, Biochemistry, Biophysics, or related field.
- Hands-on experience with LC‑MS or MS/MS for glycan or glycoprotein structural characterization.
- Strong analytical reasoning and the ability to interpret complex structure–function relationships.
- Excellent communication skills and ability to work effectively in a cross-functional, matrixed environment.
Benefits
- company-sponsored medical, dental, vision, and life insurance plans*
- paid time off
- discretionary annual bonus
- discretionary stock-based long-term incentives (eligibility may vary based on role)
Applicant Tracking System Keywords
Tip: use these terms in your resume and cover letter to boost ATS matches.
Hard skills
N-glycan analysisHILIC-FLDLC-MSCE-LIFmass spectrometryglycopeptide mappingexoglycosidase sequencinglinkage analysismonosaccharide analysiscomputational structure–function modeling
Soft skills
analytical reasoningcommunication skillscross-functional collaboration