Medical Director / Senior Medical Director, Clinical Development

Cullinan Oncology

Medical Director/Senior Medical Director in Clinical Development for Cullinan Therapeutics. Leading clinical trials and collaborating on a T-cell engager program for AML.

Posted 5/19/2026full-timeRemote • 🇺🇸 United StatesSenior💰 $300,000 - $390,000 per yearWebsite

About the role

Key responsibilities & impact

Serves as the medical monitor for clinical trials and assists in resolving major issues that may affect their assigned studies.
Partners with the Clinical Scientist, Data Manager, Pharmacovigilance Scientist, and other members of the study team to conduct the clinical studies, including study design, operational feasibility assessment, and site selection.
Provides expert opinion and review for creation of key study documents, including clinical study protocols, safety and medical monitoring plans, charters, and informed consent forms.
Interacts closely with Regulatory Affairs to contribute or review clinically relevant components of investigator brochures, briefing books, and other regulatory documents and communications.
Conducts investigator meetings, leads site initiation visits, and maintains relationships with clinical trial investigators.
Works with internal discovery and translational scientists, technical operations/manufacturing teams, regulatory affairs, safety and pharmacovigilance, and external consultants or CROs in a cross-functional manner.
Oversees and supports the gathering, analyzing, reviewing, interpreting, and reporting of clinical safety and efficacy data.
Supports publication and external communication strategy, acting as owner of clinical data, collaborating in the creation of meeting abstracts, presentations, and publications, and presenting at investigator meetings and scientific conferences as required.

Requirements

What you’ll need

MD, DO, or equivalent medical degree with experience in patient care at the graduate medical level and beyond. Board certification or substantial clinical experience in hematology, medical oncology, hematology-oncology.
At least 3-5 years of experience in clinical investigation in a pharmaceutical or biotechnology company, or equivalent academic clinical trial leadership experience. The Senior Medical Director level typically requires broader independent program leadership experience.
Experience in oncology drug development, clinical trial design, medical monitoring, and interpretation of safety and efficacy data.
Working knowledge of Good Clinical Practice, clinical trial conduct, and regulatory expectations for oncology development.
Demonstrated ability to make independent, timely, and appropriate decisions in a fast-paced biotechnology environment.
Excellent interpersonal, verbal, and written communication skills, with the ability to effectively collaborate with cross-functional teams and external stakeholders.
Direct experience in AML, myeloid malignancies, or leukemia drug development (strongly preferred).
Experience with T-cell engager, bispecific antibody, cellular therapy, or other immune effector therapies, including CRS/ICANS risk management (strongly preferred).

Benefits

Comp & perks

Annual bonus opportunity (25% of salary)
Annual equity awards
Medical, dental, vision, life and disability insurance
401(K) plan with employer match
Stock options
Employee stock purchase plan
Flexible non-accrual paid time off
Paid holidays
End-of-year shut down
Cell phone reimbursement
Tuition reimbursement
Paid parental leave

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

clinical trial designmedical monitoringsafety data interpretationefficacy data interpretationoncology drug developmentGood Clinical Practiceregulatory expectationsT-cell engagerbispecific antibodycellular therapy

Soft Skills

interpersonal skillsverbal communicationwritten communicationcollaborationdecision makingleadership

Certifications

MDDOboard certification in hematologyboard certification in medical oncology