Senior Process Engineer – Small Molecule, Oligo, Peptide

CRB

Senior Process Engineer focusing on small molecule manufacturing, design, and optimization at CRB. Leading projects that ensure regulatory compliance and mentoring junior staff.

Posted 6/2/2026full-timeRemote • Colorado • 🇺🇸 United StatesSenior💰 $100,000 - $165,000 per yearWebsite

About the role

Key responsibilities & impact

Lead and support client projects focused on small molecule API process development, scale-up, and manufacturing optimization
Conduct site assessments, gap analyses, and provide recommendations for process improvements and compliance
Develop process flow diagrams (PFDs), piping and instrumentation diagrams (P&IDs), and mass/energy balances
Translate client requirements into actionable design scope and document decisions, open issues, and action items
Identify and escalate scope changes or design deviations to project leadership
Collaborate with cross-functional teams including architecture, mechanical, electrical, and construction
Prepare technical reports, proposals, and presentations for internal and client stakeholders
Support capital project planning including feasibility studies, equipment selection, and facility design
Ensure alignment with industry standards including cGMP, FDA, EMA, and ICH guidelines
Participate in advanced project activities such as: Technical bid tabulations Vendor package management Factory acceptance testing Risk assessments (e.g., HAZOP, HACCP) 3D model reviews and coordination Sequence of operations and functional specification reviews
Mentor junior engineers and design staff

Requirements

What you’ll need

Bachelor’s or Master’s degree in Chemical Engineering or a related discipline (ABET-accredited)
Minimum of 5 years of experience in small molecule process engineering, preferably in a consulting or client-facing role
Strong understanding of chemical synthesis, purification, and formulation processes
Experience in design firm or operating company settings within a related industry
Strong written and verbal communication skills
Intermediate experience with applicable industry and regulatory guidance and building codes
Advanced technical knowledge and experience with small molecule API manufacturing equipment and utility systems, such as chemical reactors, filters, centrifuges, dryers, vacuum pumps, scrubbers, purified water, process compressed gases, and engineered heat transfer fluid systems
Experience designing and implementing engineering controls for containment of highly potent APIs
Experience with cGMP practices within regulated industries (FDA, EMA, JP, etc.)

Benefits

Comp & perks

comprehensive insurance coverage
opportunity to participate in one or more annual incentive programs based on company and individual performance

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

small molecule API process developmentscale-upmanufacturing optimizationprocess flow diagramspiping and instrumentation diagramsmass/energy balanceschemical synthesispurification processesformulation processesengineering controls for containment

Soft Skills

leadershipcollaborationcommunicationmentoringproblem-solvingtechnical writingproject managementanalytical thinkingclient-facing skillsrecommendation development

Certifications

Bachelor’s degree in Chemical EngineeringMaster’s degree in Chemical Engineering