Senior Clinical Research Scientist II

Caribou Biosciences

Senior Clinical Research Scientist II overseeing CAR-T clinical trials at Caribou Biosciences. Leading execution of early-phase trials while ensuring patient safety and data integrity.

Posted 5/26/2026full-timeRemote • California • 🇺🇸 United StatesSenior💰 $215,000 - $230,000 per yearWebsite

ATS Keywords

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Hard Skills

clinical study executiondata reviewsafety monitoringadverse event reviewdose escalation decisionsscientific writingclinical data interpretationbiomarker data analysisregulatory submissionsclinical trial protocols

Soft Skills

cross-functional collaborationcommunication skillsleadershipdata informed decision makingscientific engagementorganizational skillstrend identificationproblem-solvingpresentation skillsteamwork

Tools & Technologies

GCPSOPsIND-related documentsclinical study reportsInvestigator’s Brochureshealth authority responsesclinical data management systemsbiostatistics toolsdata management softwareclinical trial management systems

Certifications & Qualifications

PhDPharmDMAMSMSNBABSBSN

Industry Keywords

hematologic malignanciesCAR-T therapycell therapyclinical developmentearly phase trialsregulatory requirementsclinical operationstranslational sciencesbiostatisticsCRO engagement

Tech Stack

Tools & technologies

Google Cloud Platform

About the role

Key responsibilities & impact

Lead clinical study in execution, including planning, conduct, data review, and reporting for Phase I and II trials in hematologic malignancies
Own ongoing clinical data review, ensuring patient safety and data integrity; identify trends and drive data informed decisions
Lead safety monitoring activities including review of adverse events and CAR-T associated toxicities (ie: CRS, ICANS) and contribute to dose escalation decisions
Drive cross-functional collaboration with Clinical Operations, Translational Sciences, Data Management, Biostatistics, Regulatory, and CMC teams to ensure high-quality study execution
Lead authorship of key study documents, including protocols, Investigator’s Brochures, clinical study reports, regulatory documents, and safety narratives
Integrate clinical and translational data (ie: cell expansion, persistence, biomarker data) to generate insights and inform program strategy
Contribute to regulatory strategy and submissions, including IND-related documents and health authority responses
Serve as a scientific lead at the study level, engaging with investigators, CROs, and key opinion leaders
Support development of publications, abstracts, and presentations for scientific conferences
Ensure compliance with GCP, internal SOPs, and regulatory requirements

Requirements

What you’ll need

PhD/PharmD with 5+ years of experience in clinical development; MA/MS/MSN and 8+ years of experience; BA/BS/BSN and 10+ years of experience
Experience in hematology-oncology drug development
Experience with CAR-T or cell therapy development
Demonstrated ownership of clinical studies, preferably early phase trials
Strong scientific writing and communication skills
Experience with GCP and regulatory requirements
Experience with clinical data review and interpretation (including data listings)
Ability to analyze and synthesize complex clinical and biomarker data
Ability to travel 30% based on business needs

Benefits

Comp & perks

Comprehensive compensation package, which includes competitive salary, bonus, and equity for all employees
Generous paid vacation time, in addition to company-observed holidays
Excellent medical, dental, and vision insurance
401(k) retirement savings plan, which includes matching employer contributions
Employee stock purchase plan (ESPP)
Tuition reimbursement program